dissolution of solids dodge form there is a calculation
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equation shown (below) that volume is in the denominator which apparently indicate that more
volume leads to lower dissolution. Explain how V in the denominator is correct and how increase
in the dissolution media volume practically enhances the dissolution rate, provide a numerical
example?
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=
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2- Define and correlate IQ, OQ, PQ, to the dissolution instrument?
3- Which drug is usually used a calibration standard for dissolution and which parameters are we
expecting to get from the calibration?
4- What is Sink condition and why it is important in dissolution?
Calibration Curve
Sample Absorbance
1
y = 0.02x
R= 1
0.8
0.6
0.4
0.2
0
0
10
20
30
40
50
Sample Conc (ïmL)
The Dose used in Dissolution (50 mg)
Solubility of Drug (z)= 300 mg/mL
Table-1
Dissolution Run-1 (Apparatus II) 900 mL
Without replacement of the medium volume
Vpull=3mL
Sample time
(min)
Sample
Absorbance
5
0.17
10
0.4
15
0.55
20
0.65
25
0.85
30
0.95
45
0.99
60
1.05
Sample Con.
(ïmL)
%LC
a) Is the drug in sink Condition? Show your calculation?
b) Complete the above table (table-1)
c) Plot the Dissolution graph (table-1)
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