BIOL 4340 Biology Nuclear Pore Protein Paper
Description
My protein is the nuclear pore protein which is located in the outer membrane of the nucleus.
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BIOL 4340 Written Assignment 2
**** SUBMIT ON D2L******
DUE Sunday, 12/11
Part 1:
Having made it through Cell Molecular Biology this far, you are now an expert on cells and
their molecular mechanisms. There are approximately 10,000 proteins in a typical cell that
are synthesized through different routes of intracellular protein trafficking. Each of you will
be given a different protein and its final location in the cell. Starting from the mRNA that is
produced and released into the cytosol, describe in detail how the protein is translated and
where this occurs. Additionally, describe how the protein is being processed and where,
along with how it is being transported or further processed until it reaches its final
destination. Depending on your protein, many will have very different routes that they follow.
Provide enough detail to complete 2 3 pages. This can be done by focusing in detail the
more complex steps; What mode(s) of protein trafficking occurs (translocation, gated
transport or vesicular transport)? Is your protein glycosylated? Does it have disulfide
bonds? If it goes to the nucleus, what size is the protein? If it simply stays in cytosol, then
you will need to provide more detail about its transcription and translation than given in
class. If it goes to several organelles, just focus detail on one part of the process.
If you are having trouble with this assignment, contact me. However, do your best at
trying on your own first so a meaningful discussion can occur.
Part 2
Look up a figure from primary literature (look under Pubmed) related to your protein. Interpret
the figure and its results. Int. J. Mol. Sci. 2019, 20, 5039.
For example, in the figure below; This represents a western blot to quantify the amount of
Glucose-6-Phophatase (G6P) in the intestine as compared to the liver. The ponceau shows the
same amount of protein was present in each lane meaning equal loading. The western blot itself
is shown in B (Above it is a graphical representation of three determinations). The graph to the
left and three lanes below are from the liver. The graph to the right and remaining lanes below
are from the intestine. Of the three species, human intestine has the highest levels of G6P.
.
Purchase answer to see full
attachment
**** SUBMIT ON D2L******
DUE Sunday, 12/11
Part 1:
Having made it through Cell Molecular Biology this far, you are now an expert on cells and
their molecular mechanisms. There are approximately 10,000 proteins in a typical cell that
are synthesized through different routes of intracellular protein trafficking. Each of you will
be given a different protein and its final location in the cell. Starting from the mRNA that is
produced and released into the cytosol, describe in detail how the protein is translated and
where this occurs. Additionally, describe how the protein is being processed and where,
along with how it is being transported or further processed until it reaches its final
destination. Depending on your protein, many will have very different routes that they follow.
Provide enough detail to complete 2 3 pages. This can be done by focusing in detail the
more complex steps; What mode(s) of protein trafficking occurs (translocation, gated
transport or vesicular transport)? Is your protein glycosylated? Does it have disulfide
bonds? If it goes to the nucleus, what size is the protein? If it simply stays in cytosol, then
you will need to provide more detail about its transcription and translation than given in
class. If it goes to several organelles, just focus detail on one part of the process.
If you are having trouble with this assignment, contact me. However, do your best at
trying on your own first so a meaningful discussion can occur.
Part 2
Look up a figure from primary literature (look under Pubmed) related to your protein. Interpret
the figure and its results. Int. J. Mol. Sci. 2019, 20, 5039.
For example, in the figure below; This represents a western blot to quantify the amount of
Glucose-6-Phophatase (G6P) in the intestine as compared to the liver. The ponceau shows the
same amount of protein was present in each lane meaning equal loading. The western blot itself
is shown in B (Above it is a graphical representation of three determinations). The graph to the
left and three lanes below are from the liver. The graph to the right and remaining lanes below
are from the intestine. Of the three species, human intestine has the highest levels of G6P.
.
Purchase answer to see full
attachment
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